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PDE Inhibitors

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa DHFR Carbonic Anhydrase

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1895 Dipyridamole Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
Nature, 2025, 10.1038/s41586-025-09755-9
Theranostics, 2024, 14(18):6947-6968
J Immunother Cancer, 2024, 12(11)e009805
S1512 Tadalafil Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM in a cell-free assay. This compound is at least 9000 times more selective for PDE5 than most of the other families of PDEs, with the exception of PDE11. It can partial inhibits PDE11
Cancers, November 06, 2019, 1740
Investigative Ophthalmology & Visual Science, November 01, 2017, 5604-5615
Investigative Ophthalmology & Visual Science, November 01 2017, 5604-5615
Verified customer review of Tadalafil
S7858 Dibutyryl cAMP (db cAMP/Bucladesine) sodium Bucladesine sodium is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor.
Cell, 2025, S0092-8674(25)00735-4
Nat Neurosci, 2025, 28(6):1174-1184
Nat Commun, 2025, 16(1):6151
S1431 Sildenafil Citrate Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.
Anticancer Research, September 2018, 5149-5157
Cancers, November 06, 2019, 1740
EMBO Molecular Medicine, December 23, 2025, Online ahead of print
Verified customer review of Sildenafil Citrate
S2131 Roflumilast Roflumilast is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM in a cell-free assay.
Cell Reports, September 11, 2014, 1265-1270
Investigative Ophthalmology & Visual Science, October 1, 2024, 38
Redox Biology, February 22, 2025, 103563
Verified customer review of Roflumilast
S4684 Sildenafil Sildenafil (Revatio, UK-92480, Viagra) is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.
Adv Sci (Weinh), 2024, 11(40):e2407712
J Immunother Cancer, 2024, 12(11)e009805
Brain, 2023, 146(6):2453-2463
Verified customer review of Sildenafil
S1430 Rolipram The PDE4 selective inhibitor, Rolipram, inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.
Elife, 2022, 11e73511
ProQuest, 2022, 30509631
Acta Pharmacol Sin, 2021, 10.1038/s41401-021-00768-4
Verified customer review of Rolipram
S2515 Vardenafil HCl Trihydrate Vardenafil HCl Trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
Investigative Ophthalmology & Visual Science, November 1, 2017, 5604-5615
Investigative Ophthalmology & Visual Science, November 01 2017, 5604-5615
bioRxiv, 2026, nan
Verified customer review of Vardenafil HCl Trihydrate
S5836 IBMX (3-Isobutyl-1-methylxanthine) IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist.
J Biomed Sci, 2025, 32(1):31
J Hematol Oncol, 2023, 16(1):30
ACS Cent Sci, 2023, 9(4):719-732
S1294 Cilostazol Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
Frontiers in Pharmacology, September 23, 2021, 749930
Journal of Cerebral Blood Flow & Metabolism, January 16, 2026, 271678X251409612
Journal of Cerebral Blood Flow & Metabolism, January 16, 2026, 271678X251409612

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