Home Immunology & Inflammation STING

STING Antagonist/Inhibitors

Other Immunology & Inflammation Related Inhibitors

CXCR AhR COX IL Receptor gp120/CD4 NOD NADPH-oxidase ROS Nrf2 NOS
Cat.No. Product Name Information Product Use Citations Product Validations
S8796 diABZI STING agonist-1 (tautomerism) diABZI STING agonist (diABZI STING agonist-1, Compound 3, Tautomerism) is a potent non-nucleotide STING agonist and has tremendous potential to improve treatment of cancer in humans.Solutions are unstable and should be fresh-prepared.
Cell Discov, 2025, 11(1):23
Nat Biomed Eng, 2025, 10.1038/s41551-025-01400-0
J Exp Med, 2025, 222(5)e20241184
S6652 H-151 H-151 is a highly potent and covalent inhibitor of STING that has noteworthy inhibitory activity both in human cells and in vivo.
Clin Transl Med, 2025, 15(3):e70235
J Neuroinflammation, 2025, 22(1):14
Cell Death Dis, 2025, 16(1):641
S1537 Vadimezan (DMXAA) Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. It is also a STING agonist with potential antineoplastic activity, potently inducing IFN-β but relatively low TNF-α expression in vitro. This compound has antiviral activity. Phase 3.
Cell Chem Biol, 2025, 32(2):280-290.e14
Commun Biol, 2025, 8(1):1470
Front Pharmacol, 2025, 16:1528459
Verified customer review of Vadimezan (DMXAA)
S6575 C-176 STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.
Nat Commun, 2025, 16(1):289
J Clin Invest, 2025, e193945
MedComm (2020), 2025, 6(10):e70411
S6667 STING inhibitor C-178 C-178 is a covalent inhibitor of STING,covalently bind to Cys91.
Nature, 2025, 647(8090):735-746
Cancers, 2025, 391
Neurosci Lett, 2025, 847:138095
E1066 SN-011 SN-011 is a STING-specific inhibitor with IC50 of 76 nM.
Nature Communications, 2025, 10983
Theranostics, 2025, 3207-3222
OncoImmunology, 2025, 2602216
S0853 SR-717 lithium SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.
Nat Commun, 2025, 16(1):3440
Pharmaceutics, 2024, 16(9)1216
Mol Neurobiol, 2022, 59(11):7006-7024
S7904 2',3'-cGAMP Sodium Salt 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). 2',3'-cGAMP binds to STING with Kd of 3.79 nM.
J Nanobiotechnology, 2025, 23(1):724
Cancer Sci, 2025, 10.1111/cas.70162
J Biol Chem, 2025, 301(10):110653
S8954 G10 (STING agonist-1) G10 (STING agonist-1) is a novel human-specific STING agonist that triggers IFN regulatory factor 3 (IRF3)/ type I interferon (IFN)-associated transcription in human fibroblasts. This compound potently reduces growth of Chikungunya virus (CHIKV) with IC90 of 8.01 μM and blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
International Journal of Biological Sciences, 2023, 3428-3440
Int J Biol Sci, 2023, 19(11):3428-3440
Dissertation, Heidelberg University, 2023, 34
S9681 MSA-2 MSA-2 is an orally available non-nucleotide human STING agonist with antitumor activity.
J Colloid Interface Sci, 2025, 686:1019-1032
Cell Discov, 2022, 8(1):133