Home Hippo YAP inhibitor - TEAD inhibitor YAP-TEAD Inhibitor 1 (Peptide 17) For research use only.

YAP-TEAD Inhibitor 1 (Peptide 17)

YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.

YAP-TEAD Inhibitor 1 (Peptide 17) Chemical Structure

YAP-TEAD Inhibitor 1 (Peptide 17) Chemical Structure

CAS No. 1659305-78-8

Purity & Quality Control

YAP-TEAD Inhibitor 1 (Peptide 17) Related Products

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Bel-7404 cells Function assay Inhibition of YAP/ GST-TEAD1 interaction in human Bel-7404 cells by GST pull-down assay, Kd=0.015 μM 25221655
Click to View More Cell Line Experimental Data

Biological Activity

Description YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
Targets
YAP/TEAD interaction [1]
(Cell-free assay)
25 nM
In vitro
In vitro The engineered peptide significantly improves the potency in disrupting YAP-TEAD interaction in vitro[1]. This 17mer peptide demonstrates a single-digit micromolar affinity to TEAD1[2].

Chemical Information & Solubility

Molecular Weight 2019.86 Formula

C93H144ClN23O21S2
CAS No. 1659305-78-8 SDF Download YAP-TEAD Inhibitor 1 (Peptide 17) SDF
Smiles CCCCC1NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCSSCC(NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CO)NC(=O)C(C)NC(=O)C3CCCN3C1=O)C(=O)NC(CCCCN)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(CCC(O)=O)C(N)=O)NC(=O)C(C
Storage (From the date of receipt)

In vitro
Batch:

Water : 40 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
Is this inhibitor cell permeable?

Answer:
The following paper states that the cyclic YAP petide at N terminus may improve the cell permeability: “Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides”

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