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Xylitol

Synonyms: Adonitol, Ribitol, Xylite, D-Xylitol, Adonite

Xylitol (Adonitol, Ribitol, Xylite, D-Xylitol, Adonite) is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.

Xylitol Chemical Structure

Xylitol Chemical Structure

CAS No. 87-99-0

Purity & Quality Control

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Biological Activity

Description Xylitol (Adonitol, Ribitol, Xylite, D-Xylitol, Adonite) is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
Targets
angiogenesis [1]
In vitro
In vitro Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression[2]. Xylitol strongly inhibits tube formation, migration, and invasion of HUVECs. Xylitol decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs[1].
Cell Research Cell lines human umbilical vein endothelial cells（HUVECs）
Concentrations 0.1, 0.3, 0.5 and 1 mM
Incubation Time 18 h
Method

In vitro tube formation assay：HUVECs (2×104 cells) are seeded on a layer of previously polymerized Matrigel and treated with or without xylitol. Matrigel culture is incubated at 37°C. After 6 h, changes in cell morphology are captured through a phase contrast microscope and photographed at ×40 magnification. Each sample is assayed in duplicate and independent experiments are repeated three times.
In Vivo
In vivo Xylitol triggers the release of insulin in dogs[3] and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug[1].
Animal Research Animal Models Specific pathogen-free (SPF) male C57BL/6 mice
Dosages 0.1 or 1 mM
Administration s.c.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03229551 Completed
Chronic Rhinosinusitis|Rhinosinusitis|Sinusitis|Drain Sinus|Endoscopic Sinus Surgery|Biofilms|Bacterial Overgrowth
Ochsner Health System|Tulane University School of Medicine
 March 1 2018 Phase 2|Phase 3

Chemical Information & Solubility

Molecular Weight 152.15 Formula

C5H12O5
CAS No. 87-99-0 SDF Download Xylitol SDF
Smiles C(C(C(C(CO)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 30 mg/mL ( (197.17 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 30 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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