Home Metabolism Vitamin chemical Vitamin A Acetate For research use only.

Vitamin A Acetate

Synonyms: Retinyl (Retinol) Acetate

Vitamin A Acetate (Retinyl, Retinol) is a group of unsaturated nutritional hydrocarbons, that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids, among which beta-carotene is the most important.

Vitamin A Acetate Chemical Structure

Vitamin A Acetate Chemical Structure

CAS No. 127-47-9

Purity & Quality Control

Vitamin A Acetate Related Products

Biological Activity

Description Vitamin A Acetate (Retinyl, Retinol) is a group of unsaturated nutritional hydrocarbons, that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids, among which beta-carotene is the most important.
In vitro
In vitro Vitamin A deficiency impairs innate immunity by impeding normal regeneration of mucosal barriers damaged by infection, and by diminishing the function of neutrophils, macrophages, and natural killer cells. Vitamin A is also required for adaptive immunity and plays a role in the development of T both-helper (Th) cells and B-cells. Vitamin A deficiency diminishes antibody-mediated responses directed by Th2 cells, although some aspects of Th1-mediated immunity are also diminished. [1]
In Vivo
In vivo Vitamin A acetate (VAA) (fed on an otherwise conventional diet) responds to 105 semiallogeneic cells (a suboptimal dose) in a host-versus-graft (HvG) reaction in mice, whereas mice on a conventional diet do not. [2] Vitamin A acetate can bring a solid and long-lasting state of tolerance induced by the intravenous injection into newborn CBA mice of lymphoid cells from (CBA X C57BL/10ScSn) F1 hybrids to an end, the effect of which is to increase the proportion of the moiety of the T-cell population that produces IL-2. [3] Vitamin A acetate-supplemented diet develops a positive skin reaction to purified protein derivative of mycobacteria in High-dose Mycobacterium bovis-infected mice, and their spleen cells show an increased IL-2 production in vitro. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06319079 Not yet recruiting
Lactating Mothers|Infants
Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri
 March 2024 Not Applicable
NCT06058442 Recruiting
Gastrectomy
University of Leipzig
 January 24 2024 Phase 3
NCT06057597 Recruiting
Obesity|Morbid
Assistance Publique - Hôpitaux de Paris
 November 13 2023 Not Applicable
NCT06081114 Recruiting
Micronutrient Status
Johns Hopkins Bloomberg School of Public Health|International Center for Diarrheal Disease Research Bangladesh (icddrb)|Bill and Melinda Gates Foundation
 October 22 2023 Not Applicable
NCT06155448 Active not recruiting
Malaria
Malaria Consortium|Nigerian Institute of Medical Research|London School of Hygiene and Tropical Medicine|Northwestern University
 August 8 2023 Not Applicable

Chemical Information & Solubility

Molecular Weight 328.49 Formula

C22H32O2
CAS No. 127-47-9 SDF Download Vitamin A Acetate SDF
Smiles CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCOC(=O)C)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 65 mg/mL ( (197.87 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 65 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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