Home GPCR & G Protein TAAR agonist Tryptamine For research use only.

Tryptamine

Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA).

Tryptamine Chemical Structure

Tryptamine Chemical Structure

CAS No. 61-54-1

Purity & Quality Control

Batch: S362701 DMSO]32 mg/mL]false]Ethanol]32 mg/mL]false]Water]Insoluble]false Purity: 99.55%
99.55

Tryptamine Related Products

Biological Activity

Description Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA).
Targets
hTAAR1 [2]
(COS-7 cells)
1.08 μM(Ki)
In vitro
In vitro High concentrations of tryptamine (0.1-1 mM) induce autophagy in HT22 and SK-N-SH nerve cell lines and in primary cultures of astrocytes, glial cells being less sensitive than neurons[2].
Cell Research Cell lines HT22 cells
Concentrations 100 nM-1 mM
Incubation Time 24 h
Method HT22 cells are incubated for 24 hr with concentrations of tryptamine or 5-methoxytryptamine between 100 nM and 1 mM.
In Vivo
In vivo Tryptamine at a dose of 50 mg/kg i.p. induces an inhibition of locomotor activity and, at doses ranging from 150 to 300 mg/kg, induces peculiar behaviors such as head twitch, head weaving, forepaw treading, hindlimb abduction and Straub tail. Tryptamine induces both the depression and excitation in the behavior of mice depending on the dosage and Tryptamine-induced excitatory behaviors may be attributed to both its direct stimulation of 5-HT receptors and facilitation of 5-HT release[3].

Chemical Information & Solubility

Molecular Weight 160.22 Formula

C10H12N2
CAS No. 61-54-1 SDF Download Tryptamine SDF
Smiles C1=CC=C2C(=C1)C(=CN2)CCN
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (199.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 32 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Tryptamine | Tryptamine supplier | purchase Tryptamine | Tryptamine cost | Tryptamine manufacturer | order Tryptamine | Tryptamine distributor