TLX agonist 1

Name: TLX agonist 1
Brand: Selleck Chemicals
SKU: S0533
Rating: 5 (1 reviews)

Synonyms: CCRP2, SUN23314

Catalog No.S0533 Purity:99.95%

TLX agonist 1 (CCRP2, SUN23314) is a modulator of orphan nuclear receptor tailless (TLX, NR2E1) with EC50 of 1.0 μM and Kd of 650 nM. TLX agonist 1 (CCRP2, SUN23314) binds to recombinant TLX protein and enhances TLX transcriptional repressive activity.

TLX agonist 1 Chemical Structure

CAS No. 958323-31-4

Purity & Quality Control

Batch: S053301 DMSO]40 mg/mL]false]Ethanol]20 mg/mL]false]Water]Insoluble]false Purity: 99.95%

99.95

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Biological Activity

Description

Targets

NR2E1 ^[1] (Cell-free assay)	NR2E1 ^[1] (Cell-free assay)
650 nM(Kd)	1.0 μM(EC50)

References

[1] Cindy Benod, et al. PLoS One. 2014 Jun 17;9(6):e99440.

Chemical Information & Solubility

Molecular Weight	374.48	Formula	C₂₃H₂₆N₄O
CAS No.	958323-31-4	SDF	--
Smiles	CC1=CC(=NN1C)C(=O)N2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 40 mg/mL ( (106.81 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble

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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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