Home Neuronal Signaling Adrenergic Receptor agonist Tizanidine For research use only.

Tizanidine

Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.

Tizanidine Chemical Structure

Tizanidine Chemical Structure

CAS No. 51322-75-9

Purity & Quality Control

Batch: S553701 DMSO]50 mg/mL]false]Water]15 mg/mL]false]Ethanol]6 mg/mL]false Purity: 98.4%
98.4

Tizanidine Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.
Targets
α2 adrenergic receptor [1]
In vitro
In vitro Like clonidine, it has sedative, anxiolytic, and analgesic properties, but it has a shorter duration of action and less effect on heart rate and blood pressure[1].
In Vivo
In vivo Tizanidine is shown to significantly reduce pain and tissue tenderness and to improve the quality of sleep[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01844674 Completed
Malignant Melanoma Neoplasms
Hoffmann-La Roche
 September 2 2013 Phase 1
NCT01839279 Completed
Spasticity
Acorda Therapeutics
 April 2013 Phase 2
NCT01405950 Terminated
Spasticity Due to Cerebral Palsy
Acorda Therapeutics|Syneos Health
 May 2011 Phase 1
NCT01065987 Completed
Healthy
Dr. Reddy''s Laboratories Limited
 September 2001 Phase 1

Chemical Information & Solubility

Molecular Weight 253.71 Formula

C9H8ClN5S
CAS No. 51322-75-9 SDF --
Smiles C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 50 mg/mL ( (197.07 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 15 mg/mL

Ethanol : 6 mg/mL


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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