Home Microbiology Reverse Transcriptase inhibitor Tenofovir alafenamide hemifumarate For research use only.

Tenofovir alafenamide hemifumarate

Synonyms: TAF hemifumarate, GS-7340 hemifumarate

Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

Tenofovir alafenamide hemifumarate Chemical Structure

Tenofovir alafenamide hemifumarate Chemical Structure

CAS No. 1392275-56-7

Purity & Quality Control

Batch: S442701 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]50 mg/mL]false Purity: 99.92%
99.92

Tenofovir alafenamide hemifumarate Related Products

Signaling Pathway

Reverse Transcriptase Signaling Pathways

Reverse Transcriptase Signaling Pathway

Biological Activity

Description Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Targets
reverse transcriptase [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05652478 Not yet recruiting
Healthy Volunteer|Weight Gain|Metabolic Effects|Integrase Strand Transfer Inhibitors
National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC)
 May 15 2024 Phase 2
NCT06104306 Recruiting
HIV-1-infection
Gilead Sciences
 December 13 2023 Phase 4
NCT05583006 Recruiting
Patient Satisfaction|Drug Adherence|Efficacy Self|Safety Issues
Taichung Veterans General Hospital|Institute of Adherence to Medication
 November 6 2023 --

Chemical Information & Solubility

Molecular Weight 1069 Formula

C46H62N12O14P2
CAS No. 1392275-56-7 SDF --
Smiles CC(C)OC(=O)C(C)N[P](=O)(COC(C)C[N]1C=NC2=C(N)N=CN=C12)OC3=CC=CC=C3.CC(C)OC(=O)C(C)N[P](=O)(COC(C)C[N]4C=NC5=C(N)N=CN=C45)OC6=CC=CC=C6.OC(=O)\C=C\C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (93.54 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : 50 mg/mL


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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