Home Autophagy Beclin activator Tat-beclin 1 (Tat-BECN1) For research use only.

Tat-beclin 1 (Tat-BECN1)

Tat-beclin 1 (Tat-BECN1), a peptide known to stimulate autophagy through mobilization of endogenous Beclin 1, induces autophagy in vitro and in vivo and improves clinical outcomes.

Tat-beclin 1 (Tat-BECN1) Chemical Structure

Tat-beclin 1 (Tat-BECN1) Chemical Structure

CAS No. 1423821-88-8

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Tat-beclin 1 (Tat-BECN1) Related Products

Biological Activity

Description Tat-beclin 1 (Tat-BECN1), a peptide known to stimulate autophagy through mobilization of endogenous Beclin 1, induces autophagy in vitro and in vivo and improves clinical outcomes.
Targets
Beclin 1 [1]
In vitro
In vitro Tat-beclin 1 is a cell-permeable peptide that induces autophagy. Treatment with Tat-beclin 1, but not Tat-scrambled, results in a dose-dependent decrease in amounts of p62, a selective autophagy substrate, and a dose-dependent conversion of the non-lipidated form of LC3, LC3-I, to the lipidated, autophagosome-associated form of LC3, LC3-II, in multiple cell lines and primary murine embryonic fibroblasts (MEFs). Tat-beclin 1 markedly inhibits HIV-1 replication in primary human monocyte-derived macrophages[1].
Cell Research Cell lines human MDMs
Concentrations 0.5–5 μM
Incubation Time 24 h
Method

For treatment of primary human MDMs, cells are washed with PBS and pre-treated with peptides (0.5-5 μM, 24 h) in 500 μl macrophage-SFM (serum-free media) before infection with HIV-1.
Experimental Result Images Methods Biomarkers Images PMID
Western blot LC3A-II / LC3B-II POU5F1 / NANOG / SOX2 TUBB3 / CSN2 27929731
In Vivo
In vivo Tat-beclin 1 can induce autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice. Daily Tat-beclin 1 peptide treatment is well-tolerated in both neonatal and adult mice. Tat-beclin 1 peptide improves the clinical outcome of mice with CNS WNV(West Nile virus) infection[1].
Animal Research Animal Models C57BL/6J mice
Dosages 15 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 3741.1 Formula

C164H251N57O45
CAS No. 1423821-88-8 SDF Download Tat-beclin 1 (Tat-BECN1) SDF
Smiles CCC(C)C(NNC(CC1=C[NH]C2=C1C=CC=C2)C(=O)NC(CC3=CN=C[NH]3)C(=O)NC(CC(O)=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CC4=CC=CC=C4)C(=O)NCC(=O)NC(C(C)O)C(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CC5=CC=CC=C5)C(=O)C(=O)C(NC(=O
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Water : 100 mg/mL


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