Tafenoquine

Name: Tafenoquine
Brand: Selleck Chemicals
SKU: E2665
Rating: 5 (1 reviews)

Synonyms: WR 238605

Catalog No.E2665 Purity:98.06%

Tafenoquine (WR 238605) is an 8-aminoquinoline, used as an anti-malarial prophylactic agent.

Tafenoquine Chemical Structure

CAS No. 106635-80-7

Purity & Quality Control

Batch: E266501 DMSO]93 mg/mL]false]Ethanol]93 mg/mL]false]Water]Insoluble]false Purity: 98.06%

98.06

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Biological Activity

Description	Tafenoquine (WR 238605) is an 8-aminoquinoline, used as an anti-malarial prophylactic agent.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT04984759	Withdrawn	Healthy Lactating Women	University of Oxford\|Mahidol Oxford Tropical Medicine Research Unit	July 1 2023	Phase 4
NCT05203744	Unknown status	Prophylaxis	Naval Medical Research Center\|Naval Medical Research Unit TWO (NAMRU-2)\|Australian Defence Force Malaria and Infectious Disease Institute (ADF MIDI)\|The 108 Military Central Hospital\|Naval Environmental Preventive Medicine Unit TWO (NEPMU-2)	May 10 2022	Phase 4
NCT02563496	Completed	Malaria Vivax	GlaxoSmithKline\|Medicines for Malaria Venture	February 6 2017	Phase 2

References

[1] Marcsisin SR, et al. Malar J. 2014 Jan 3;13:2.

Chemical Information & Solubility

Molecular Weight	463.49	Formula	C₂₄H₂₈F₃N₃O₃
CAS No.	106635-80-7	SDF	--
Smiles	COC1=NC2=C(C(=C1)C)C(=C(OC)C=C2NC(C)CCCN)OC3=CC(=CC=C3)C(F)(F)F
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 93 mg/mL ( (200.65 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 93 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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