Home Proteases HIV Protease inhibitor Saquinavir Mesylate For research use only.

Saquinavir Mesylate

Synonyms: Ro 31-8959/003

Saquinavir mesylate (Ro 31-8959/003) is a potent inhibitor of HIV Protease used in antiretroviral therapy. It blocks proteolysis of polyproteins containing either wild-type or single-chain dimer retroviral proteinase (PR).

Saquinavir Mesylate Chemical Structure

Saquinavir Mesylate Chemical Structure

CAS No. 149845-06-7

Purity & Quality Control

Batch: E446601 DMSO]50 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.05%
99.05

Saquinavir Mesylate Related Products

Signaling Pathway

HIV Protease Signaling Pathways

HIV Protease Signaling Pathway

Biological Activity

Description Saquinavir mesylate (Ro 31-8959/003) is a potent inhibitor of HIV Protease used in antiretroviral therapy. It blocks proteolysis of polyproteins containing either wild-type or single-chain dimer retroviral proteinase (PR).
Targets
HIV protease [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00476983 Withdrawn
Saquinavir/Ritonavir BID or Lopinavir/Ritonavir BID
The HIV Netherlands Australia Thailand Research Collaboration
 Phase 2|Phase 3

Chemical Information & Solubility

Molecular Weight 766.95 Formula

C38H50N6O5.CH4O3S
CAS No. 149845-06-7 SDF Download Saquinavir Mesylate SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 50 mg/mL ( (65.19 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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