Home Ubiquitin E3 Ligase inhibitor - PROTAC chemical - Androgen Receptor inhibitor - E3 ligase Ligand chemical (S,R,S)-AHPC (MDK7526) For research use only.

(S,R,S)-AHPC (MDK7526)

Synonyms: VH032-NH2, VHL ligand 1

(S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.

(S,R,S)-AHPC (MDK7526) Chemical Structure

(S,R,S)-AHPC (MDK7526) Chemical Structure

CAS No. 1448297-52-6

Purity & Quality Control

Batch: S009701 DMSO]86 mg/mL]false]Ethanol]86 mg/mL]false]Water]10 mg/mL]false Purity: 99.81%
99.81

(S,R,S)-AHPC (MDK7526) Related Products

Signaling Pathway

E3 Ligase Signaling Pathways

E3 Ligase Signaling Pathway

Biological Activity

Description (S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.
Targets
Androgen Receptor [1]

Chemical Information & Solubility

Molecular Weight 430.56 Formula

C22H30N4O3S
CAS No. 1448297-52-6 SDF --
Smiles CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)N)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 86 mg/mL ( (199.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 86 mg/mL

Water : 10 mg/mL


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In vivo
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