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Risdiplam
Synonyms: RG7916, RO7034067
Risdiplam is an orally administered SMN2 pre-mRNA splicing modifier that distributes into the central nervous system (CNS) and peripheral tissues.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Risdiplam Chemical Structure
CAS No. 1825352-65-5
Purity & Quality Control
Batch:
S692501
DMSO]Insoluble]false]Water]Insoluble]false]Ethanol]Insoluble]false
Purity:
99.58%
99.58
Risdiplam Related Products
| Related Targets | SMN2 | Click to Expand |
|---|---|---|
| Related Products | Branaplam (LMI070) | Click to Expand |
| Related Compound Libraries | FDA-approved Drug Library Natural Product Library Apoptosis Compound Library DNA Damage/DNA Repair compound Library Cell Cycle compound library | Click to Expand |
Biological Activity
| Description | Risdiplam is an orally administered SMN2 pre-mRNA splicing modifier that distributes into the central nervous system (CNS) and peripheral tissues.This product has poor solubility, animal experiments are available, cell experiments please choose carefully! | |
|---|---|---|
| Targets |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05861999 | Recruiting | Muscular Atrophy Spinal |
Hoffmann-La Roche |
May 31 2024 | Phase 4 |
| NCT05861986 | Recruiting | Muscular Atrophy Spinal |
Hoffmann-La Roche |
April 29 2024 | Phase 4 |
| NCT05808764 | Not yet recruiting | Muscular Atrophy Spinal |
Hoffmann-La Roche |
April 15 2024 | Phase 2 |
| NCT05769465 | Recruiting | Spinal Muscular Atrophy |
Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
April 1 2023 | -- |
| NCT05115110 | Recruiting | Spinal Muscular Atrophy (SMA) |
Hoffmann-La Roche |
June 2 2022 | Phase 2|Phase 3 |
| NCT04718181 | Completed | Muscular Atrophy Spinal |
Hoffmann-La Roche |
February 1 2021 | Phase 1 |
Chemical Information & Solubility
| Molecular Weight | 401.46 | Formula | C22H23N7O |
| CAS No. | 1825352-65-5 | SDF | -- |
| Storage (From the date of receipt) | 3 years -20°C powder | ||
|
In vitro |
DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Water : Insoluble Ethanol : Insoluble |
Molecular Weight Calculator |
|
In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Preparing Stock Solutions
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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