Home Endocrinology & Hormones RAAS inhibitor Quinapril HCl For research use only.

Quinapril HCl

Synonyms: CI-906, PD-109452-2

Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.

Quinapril HCl Chemical Structure

Quinapril HCl Chemical Structure

CAS No. 82586-55-8

Purity & Quality Control

Quinapril HCl Related Products

Signaling Pathway

RAAS Signaling Pathways

RAAS Signaling Pathway

Biological Activity

Description Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.
Targets
ACE [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00930722 Completed
Hypertension
Pfizer
 June 2009 --
NCT00980187 Completed
Hypertension|Type 2 Diabetes Mellitus
LaborMed Pharma S.A.
 March 2008 Phase 4
NCT00147524 Completed
Menopause|Hypertension
Pfizer
 October 2003 Phase 4

Chemical Information & Solubility

Molecular Weight 474.98 Formula

C25H30N2O5.HCl
CAS No. 82586-55-8 SDF Download Quinapril HCl SDF
Smiles CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 94 mg/mL ( (197.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 94 mg/mL

Ethanol : 94 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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