Home Metabolism phosphatase inhibitor PTP Inhibitor I For research use only.

PTP Inhibitor I

Synonyms: α-Bromo-4-hydroxyacetophenone, 2-Bromo-4'-hydroxyacetophenone, 4-Hydroxyphenacyl bromide, SHP-1 Inhibitor II

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.

PTP Inhibitor I Chemical Structure

PTP Inhibitor I Chemical Structure

CAS No. 2491-38-5

Purity & Quality Control

Batch: S369601 DMSO]43 mg/mL]false]Ethanol]43 mg/mL]false]Water]Insoluble]false Purity: 99.21%
99.21

PTP Inhibitor I Related Products

Biological Activity

Description PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.
Targets
PTP1B [1]
(Cell-free assay)		 SHP-1(ΔSH2) [1]
(Cell-free assay)
42 μM(Ki) 43 μM(Ki)
In vitro
In vitro PTP Inhibitor I binds to PTPs with the highest affinity, having Ki values of 43 and 42 μM and Kinact values of 0.40 and 0.57/min for SHP-1(△SH2) and PTP1B, respectively. It has lower affinity to wild-type SHP-1 than its catalytic domain (K= 530 vs 43 μM), likely due to the fact that the SH2 domains can directly bind to the PTP active site and interfere with substrate/inhibitor binding[1].
Cell Research Cell lines human B cells
Concentrations 30, 100, 300, 1000 μM
Incubation Time 3 mins
Method After incubation with varying concentrations of PTP Inhibitor I for 3 min, the cells are lysed, and the cellular proteins are separated on an SDS-PAGE gel, followed by western blot analysis.

Chemical Information & Solubility

Molecular Weight 215.04 Formula

C8H7BrO2
CAS No. 2491-38-5 SDF Download PTP Inhibitor I SDF
Smiles C1=CC(=CC=C1C(=O)CBr)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 43 mg/mL ( (199.96 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 43 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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