Home Neuronal Signaling Dopamine Receptor antagonist Pridopidine For research use only.

Pridopidine

Synonyms: ACR16, ASP2314, FR310826

Pridopidine (ACR16, ASP2314, FR310826) , a dopamine (DA) stabilizer, acts as an antagonist against sigma 1 receptor (S1R) and dopamine D2 receptor (D2R).

Pridopidine Chemical Structure

Pridopidine Chemical Structure

CAS No. 346688-38-8

Purity & Quality Control

Batch: E125801 DMSO]57 mg/mL]false]Ethanol]57 mg/mL]false]Water]Insoluble]false Purity: 98.59%
98.59

Pridopidine Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Pridopidine (ACR16, ASP2314, FR310826) , a dopamine (DA) stabilizer, acts as an antagonist against sigma 1 receptor (S1R) and dopamine D2 receptor (D2R).
Targets
D2R [1] S1R [1]
70-80 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03019289 Completed
Health Volunteers Huntington Disease
Prilenia
 April 19 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 281.42 Formula

C15H23NO2S
CAS No. 346688-38-8 SDF --
Smiles CCCN1CCC(CC1)C2=CC(=CC=C2)[S;v6](C)(=O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 57 mg/mL ( (202.54 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 57 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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