Home Neuronal Signaling Adrenergic Receptor antagonist Prazosin For research use only.

Prazosin

Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.

Prazosin Chemical Structure

Prazosin Chemical Structure

CAS No. 19216-56-9

Purity & Quality Control

Batch: S578001 DMSO]77 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.81%
99.81

Prazosin Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.
Targets
α1-adrenergic receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05189977 Terminated
Post-traumatic Stress Disorder (PTSD)
Otsuka Pharmaceutical Development & Commercialization Inc.|Iqvia Pty Ltd
 September 7 2022 Phase 1
NCT04365257 Terminated
COVID-19
Johns Hopkins University|Fast Grants
 May 13 2020 Phase 2
NCT03045016 Completed
Acute Stress Disorder
Hospices Civils de Lyon
 April 21 2017 Phase 2
NCT02193256 Completed
Cigarette Smoking|Alcohol Use Disorders
Yale University|National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 July 2014 Early Phase 1
NCT01178138 Completed
Continuous Methamphetamine Abuse
University of Arkansas|National Institute on Drug Abuse (NIDA)
 December 2009 Phase 2

Chemical Information & Solubility

Molecular Weight 383.40 Formula

C19H21N5O4
CAS No. 19216-56-9 SDF --
Smiles COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 77 mg/mL ( (200.83 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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