Home Neuronal Signaling P2 Receptor inhibitor Prasugrel Hydrochloride For research use only.

Prasugrel Hydrochloride

Synonyms: Prasugrel HCl, LY640315,PCR 4099 Hydrochloride

Prasugrel hydrochloride (Prasugrel HCl, LY640315,PCR 4099 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.

Prasugrel Hydrochloride Chemical Structure

Prasugrel Hydrochloride Chemical Structure

CAS No. 389574-19-0

Purity & Quality Control

Batch: S463701 DMSO]46 mg/mL]false]Ethanol]9 mg/mL]false]Water]Insoluble]false Purity: 99.53%
99.53

Prasugrel Hydrochloride Related Products

Signaling Pathway

P2 Receptor Signaling Pathways

P2 Receptor Signaling Pathway

Biological Activity

Description Prasugrel hydrochloride (Prasugrel HCl, LY640315,PCR 4099 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.
Targets
P2Y12 [1]
In Vivo
In vivo

Prasugrel significantly inhibits arterio-venous (AV) shunt and electrically induced arterial thrombosis in single dose ranges of 0.3 to 3 mg/kg and of 0.3 and 1 mg/kg/day for multiple doses. These doses are similar to doses with inhibition of platelet activation via P2Y12 receptors, suggesting that the protective effects of prasugrel in these cerebral infarction and peripheral arterial occlusive disease models reflect P2Y12 inhibitions on platelets by prasugrel's active metabolite. Prasugrel also significantly prevents progression of peripheral vascular lesions[1].
Animal Research Animal Models Sprague-Dawley rats; Wistar rats
Dosages 0.03-10 mg/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 409.9 Formula

C20H20FNO3S.HCl
CAS No. 389574-19-0 SDF Download Prasugrel Hydrochloride SDF
Smiles CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 46 mg/mL ( (112.22 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 9 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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