PVP (Polyvinylpyrrolidone)

Name: PVP (Polyvinylpyrrolidone)
Brand: Selleck Chemicals
SKU: S3596
Rating: 5 (1 reviews)

Synonyms: Polyvidone, Povidone

Catalog No.S3596 Purity:98.15%

PVP (Polyvinylpyrrolidone) is an inert, water-soluble, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. Polyvinylpyrrolidone has been widely tested and used as an effective wound healing accelerator.

PVP (Polyvinylpyrrolidone) Chemical Structure

CAS No. 9003-39-8

Purity & Quality Control

Batch: S359601 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 98.15%

98.15

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Biological Activity

Description	PVP (Polyvinylpyrrolidone) is an inert, water-soluble, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. Polyvinylpyrrolidone has been widely tested and used as an effective wound healing accelerator.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05745467	Withdrawn	SARS-CoV-2 Acute Respiratory Disease	University of Iowa\|3M	July 3 2024	Phase 4
NCT06379243	Recruiting	Osteoporosis Fracture\|Osteoporosis Vertebral\|Compression Fracture\|Perform PVP / PKP Treatment	The Seventh Affiliated Hospital of Sun Yat-sen University\|The Fourth Affiliated Hospital of Guangzhou Medical University\|Huizhou Municipal Central Hospital\|Dongguan Hospital of Traditional Chinese Medicine	December 1 2023	Not Applicable
NCT05696132	Not yet recruiting	MRSA	Nantes University Hospital	February 2023	Phase 2
NCT05587179	Completed	Unconsciousness	Centre for Evidence-Based Practice Belgium\|University Hospital Antwerp	December 21 2022	Not Applicable

References

Chemical Information & Solubility

Molecular Weight		Formula	(C₆H₉NO)_n
CAS No.	9003-39-8	SDF	--
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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