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PK 11195

Synonyms: RP 52028

PK 11195 (RP 52028) is a translocator protein (TSPO) ligand, a potent and selective antagonist of peripheral benzodiazepine receptorwith high affinity Ki of 3.1 nM in cerebellum and 4.1 nM in spinal cord. It is also an antagonist of human constitutive androstane receptor (hCAR), and human pregnane X receptor (PXR). It displaces [3H] RO5-4864 from its binding sites across organs and also targets Leishmania in chemotherapy.

PK 11195 Chemical Structure

PK 11195 Chemical Structure

CAS No. 85532-75-8

Purity & Quality Control

Batch: E463701 DMSO]71 mg/mL]false]Ethanol]17 mg/mL]false]Water]Insoluble]false Purity: 98.70%
98.70

PK 11195 Related Products

Biological Activity

Description PK 11195 (RP 52028) is a translocator protein (TSPO) ligand, a potent and selective antagonist of peripheral benzodiazepine receptorwith high affinity Ki of 3.1 nM in cerebellum and 4.1 nM in spinal cord. It is also an antagonist of human constitutive androstane receptor (hCAR), and human pregnane X receptor (PXR). It displaces [3H] RO5-4864 from its binding sites across organs and also targets Leishmania in chemotherapy.
Targets
PBR in cerebellum [1] PBR in spinal cord [1]
3.1 nM(Ki) 4.1 nM(Ki)

Chemical Information & Solubility

Molecular Weight 352.86 Formula

C21H21ClN2O
CAS No. 85532-75-8 SDF Download PK 11195 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 71 mg/mL ( (201.21 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 17 mg/mL

Water : Insoluble


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