Home Metabolism Retinoid Receptor agonist Palovarotene For research use only.

Palovarotene

Synonyms: R 667, Ro 3300074

Palovarotene (R 667; Ro 3300074) is a nuclear retinoic acid receptor γ (RAR-γ) agonist. It reduces heterotopic ossification (HO) in cultures and in murine and rat fibrodysplasia ossificans progressiva (FOP) models.

Palovarotene Chemical Structure

Palovarotene Chemical Structure

CAS No. 410528-02-8

Purity & Quality Control

Batch: E144501 DMSO]83 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.83%
99.83

Palovarotene Related Products

Biological Activity

Description Palovarotene (R 667; Ro 3300074) is a nuclear retinoic acid receptor γ (RAR-γ) agonist. It reduces heterotopic ossification (HO) in cultures and in murine and rat fibrodysplasia ossificans progressiva (FOP) models.
Targets
RARγ [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06089616 Not yet recruiting
Fibrodysplasia Ossificans Progressiva
Ipsen
 April 15 2024 --
NCT02190747 Completed
Fibrodysplasia Ossificans Progressiva
Clementia Pharmaceuticals Inc.|Ipsen
 July 14 2014 Phase 2

Chemical Information & Solubility

Molecular Weight 414.54 Formula

C27H30N2O2
CAS No. 410528-02-8 SDF Download Palovarotene SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 83 mg/mL ( (200.22 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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