Home Neuronal Signaling Dopamine Receptor antagonist Paliperidone Palmitate For research use only.

Paliperidone Palmitate

Synonyms: 9-hydroxyrisperidone palmitate

Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.

Paliperidone Palmitate Chemical Structure

Paliperidone Palmitate Chemical Structure

CAS No. 199739-10-1

Purity & Quality Control

Batch: S562401 Ethanol]3 mg/mL]false]DMSO]1 mg/mL]false]Water]Insoluble]false Purity: 99.06%
99.06

Paliperidone Palmitate Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02532842 Completed
Schizophrenia
Janssen Pharmaceutica N.V. Belgium
 July 2015 --
NCT01584466 Withdrawn
Schizophrenia
University of Maryland Baltimore
 January 2014 Not Applicable
NCT01926912 Completed
Schizophrenia
Janssen-Cilag International NV
 May 2013 --
NCT01211704 Withdrawn
Bipolar Disorder
University of Miami|Ortho-McNeil Inc.
 October 2010 Phase 4
NCT01051531 Completed
Schizophrenia
Johnson & Johnson Pte Ltd
 April 2010 Phase 3

Chemical Information & Solubility

Molecular Weight 664.89 Formula

C39H57FN4O4
CAS No. 199739-10-1 SDF --
Smiles CCCCCCCCCCCCCCCC(=O)OC1CCCN2C1=NC(=C(C2=O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Ethanol : 3 mg/mL

DMSO : 1 mg/mL ( (1.5 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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