Home DNA Damage/DNA Repair PARP inhibitor Nesuparib For research use only.

Nesuparib

Synonyms: JPI-547, NOV140201

Nesuparib (JPI-547, NOV140201) is a potential inhibitor of both PARP and tankyrases, with IC50 of 0.005 μM, 0.001 μM, 0.002 μM, and ND for TNKS1, TNKS2, PARP1, and PARP2, respectively. Nesuparib exhibits anti-tumor activity in BRCA-deficient xenograft models.

Nesuparib Chemical Structure

Nesuparib Chemical Structure

CAS No. 2055357-64-5

Purity & Quality Control

Batch: E142501 DMSO]26 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.81%
99.81

Nesuparib Related Products

Signaling Pathway

PARP Signaling Pathways

PARP Signaling Pathway

Biological Activity

Description Nesuparib (JPI-547, NOV140201) is a potential inhibitor of both PARP and tankyrases, with IC50 of 0.005 μM, 0.001 μM, 0.002 μM, and ND for TNKS1, TNKS2, PARP1, and PARP2, respectively. Nesuparib exhibits anti-tumor activity in BRCA-deficient xenograft models.
Targets
PARP2 [1] TNKS2 [1] PARP1 [1] TNKS1 [1]
0.001 μM 0.002 μM 0.005 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04335604 Completed
Advanced Solid Tumors
Onconic Therapeutics Inc.|Jeil Pharmaceutical Co. Ltd.
 December 6 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 400.48 Formula

C23H24N6O
CAS No. 2055357-64-5 SDF Download Nesuparib SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 26 mg/mL ( (64.92 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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