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Nadolol

Synonyms: Corgard, Solgol, Anabet, SQ11725

Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.

Nadolol Chemical Structure

Nadolol Chemical Structure

CAS No. 42200-33-9

Purity & Quality Control

Batch: S502301 DMSO]61 mg/mL]false]]]false]]]false Purity: 99.98%
99.98

Nadolol Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.
Targets
β-adrenergic receptor [3]
In vitro
In vitro Nadolol is a new beta-adrenoceptor blocking agent without intrinsic sympathomimetic action and with an extremely long plasma half life[2]. Nadolol antagonizes isoproterenol-induced tachycardia and ouabain-induced arrhythmias in cats, antagonizes coronary artery ligation-induced ventricular fibrillation and suppresses ventricular ectopic activity during vagal stimulation in dogs[1].
In Vivo
In vivo In several experimental models (mongrel cats and mongrel dogs), nadolol is effective against cardiac arrhythmias. This anti-arrhythmic activity appears to be related to fi-adrenergic receptor blockade, an action that would antagonize the ability of catecholamines to induce arrhythmias by alteration of cardiac automaticity and conductivity. It is also effective in preventing ventricular fibrillation induced by ligation of the left anterior descending coronary artery. Nadolol has been demonstrated to have a half-life of 4 to 5 hr in animals. It does not block neuromuscular transmission at the junction of the vagus and heart. Furthermore, nadolol does not depress excitability of the heart, as demonstrated by the lack of effect on diastolic threshold in the intact heart of the dog[1]. It is rapidly absorbed from the gastrointestinal tract and remarkalely well-tolerated when given in extremely large doses[3].
Animal Research Animal Models Male mongrel cats, 3.0 to 5.0 kg
Dosages 0.001-0.1 mg/kg
Administration i.v.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01010308 Completed
Infantile Hemangioma
The Hospital for Sick Children
 November 2009 Phase 2

Chemical Information & Solubility

Molecular Weight 309.40 Formula

C17H27NO4
CAS No. 42200-33-9 SDF --
Smiles CC(C)(C)NCC(COC1=CC=CC2=C1CC(C(C2)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 61 mg/mL ( (197.15 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

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