Home Proteases Others N-p-Tosyl-L-phenylalanine chloromethyl ketone For research use only.

N-p-Tosyl-L-phenylalanine chloromethyl ketone

Synonyms: Tosyl phenylalanyl chloromethyl ketone, TPCK

N-p-Tosyl-L-phenylalanine chloromethyl ketone (Tosyl phenylalanyl chloromethyl ketone, TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis.

N-p-Tosyl-L-phenylalanine chloromethyl ketone Chemical Structure

N-p-Tosyl-L-phenylalanine chloromethyl ketone Chemical Structure

CAS No. 402-71-1

Purity & Quality Control

Batch: E403001 DMSO]70 mg/mL]false]Ethanol]18 mg/mL]false]Water]Insoluble]false Purity: 99.33%
99.33

N-p-Tosyl-L-phenylalanine chloromethyl ketone Related Products

Biological Activity

Description N-p-Tosyl-L-phenylalanine chloromethyl ketone (Tosyl phenylalanyl chloromethyl ketone, TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis.

Chemical Information & Solubility

Molecular Weight 351.85 Formula

C17H18ClNO3S
CAS No. 402-71-1 SDF Download N-p-Tosyl-L-phenylalanine chloromethyl ketone SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 70 mg/mL ( (198.94 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 18 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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