Home Epigenetics Epigenetic Reader Domain inhibitor MS417 For research use only.

MS417

Synonyms: GTPL7512

MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM).

MS417 Chemical Structure

MS417 Chemical Structure

CAS No. 916489-36-6

Purity & Quality Control

Batch: S761501 DMSO]14 mg/mL]false]Ethanol]2 mg/mL]false]Water]Insoluble]false Purity: 98.28%
98.28

MS417 Related Products

Signaling Pathway

Epigenetic Reader Domain Signaling Pathways

Epigenetic Reader Domain Signaling Pathway

Biological Activity

Description MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM).
Targets
BRD4-BD2 [1] BRD4-BD1 [1] BRD4-BD1 [1] BRD4-BD2 [1]
25.4 nM(Kd) 30 nM 36.1 nM(Kd) 46 nM

Chemical Information & Solubility

Molecular Weight 414.9 Formula

C20H19ClN4O2S
CAS No. 916489-36-6 SDF Download MS417 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 14 mg/mL ( (33.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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