Home Neuronal Signaling COX inhibitor - FTO inhibitor Meclofenamate Sodium For research use only.

Meclofenamate Sodium

Synonyms: CI 583

Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.

Meclofenamate Sodium Chemical Structure

Meclofenamate Sodium Chemical Structure

CAS No. 6385-02-0

Purity & Quality Control

Meclofenamate Sodium Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.
Targets
COX-1 [1] COX-2 [1]
40 nM 50 nM

Chemical Information & Solubility

Molecular Weight 318.13 Formula

C14H11Cl2NO2.Na
CAS No. 6385-02-0 SDF Download Meclofenamate Sodium SDF
Smiles CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)[O-])Cl.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 63 mg/mL ( (198.03 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 63 mg/mL

Ethanol : 63 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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