Home Transmembrane Transporters TRP Channel agonist MDR-652 For research use only.

MDR-652

MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity.

MDR-652 Chemical Structure

MDR-652 Chemical Structure

CAS No. 1933528-96-1

Purity & Quality Control

Batch: S082501 DMSO]90 mg/mL]false]Ethanol]90 mg/mL]false]Water]Insoluble]false Purity: 99.94%
99.94

MDR-652 Related Products

Biological Activity

Description MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity.
Targets
hTRPV1 [1]
(Cell-free assay)		 rTRPV1 [1]
(Cell-free assay)
11.4 nM(Ki) 23.8 nM(Ki)

Chemical Information & Solubility

Molecular Weight 447.95 Formula

C22H23ClFN3O2S
CAS No. 1933528-96-1 SDF --
Smiles CC(C)(C)C1=NC(=C(S1)CNC(=O)NC2=CC(=C(C=C2)CO)F)C3=CC(=CC=C3)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 90 mg/mL ( (200.91 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 90 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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