Manelimab (Anti-B7-H1 / PD-L1 / CD274)

Synonyms: BCD-135

Catalog No.A2780 Purity:≥99%

Manelimab (Anti-B7-H1 / PD-L1 / CD274) is a monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. MW: 143.68 kD.

Purity & Quality Control

≥99

Choose Selective PD-1/PD-L1 Inhibitors

Name	Citation	PD-1/PD-L1 interaction	PD-1	PD-1/PD-L1
GS-4224	0	++++		++++
INCB086550	0	++		++
BMS-1001	0	+		+
BMS-1166	5	+++
PD-1/PD-L1 Inhibitor 3	12	+++
BMS-1	12	++
BMS202	21	+
CA-170 (AUPM-170)			✔
SR 0987		✔		IL17,RORγt
Spartalizumab (anti-PD-1)		✔
Camrelizumab (anti-PD-1)		✔
AUNP-12			✔

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Manelimab (Anti-B7-H1 / PD-L1 / CD274) is a monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. MW: 143.68 kD.

References
[1] Kononov AV, et al. WO2022124950A1.

References

[1] Kononov AV, et al. WO2022124950A1.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2168561-26-8
Molecular Weight	143.68
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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