Home DNA Damage/DNA Repair ATM/ATR inhibitor Lartesertib (M4076) For research use only.

Lartesertib (M4076)

Lartesertib (M4076) inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.

Lartesertib (M4076) Chemical Structure

Lartesertib (M4076) Chemical Structure

CAS No. 2495096-26-7

Purity & Quality Control

Lartesertib (M4076) Related Products

Signaling Pathway

ATM/ATR Signaling Pathways

ATM/ATR Signaling Pathway

Biological Activity

Description Lartesertib (M4076) inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.
Targets
ATM [1]
0.2 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05396833 Recruiting
Metastatic or Locally Advanced Unresectable Solid Tumors
EMD Serono Research & Development Institute Inc.|Merck KGaA Darmstadt Germany|EMD Serono
 June 7 2022 Phase 1
NCT04882917 Completed
Advanced Solid Tumors
EMD Serono Research & Development Institute Inc.|Merck KGaA Darmstadt Germany|EMD Serono
 May 24 2021 Phase 1

Chemical Information & Solubility

Molecular Weight 448.45 Formula

C23H21FN6O3
CAS No. 2495096-26-7 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 90 mg/mL ( (200.69 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 24 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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