Home Metabolism GLUT inhibitor KL-11743 For research use only.

KL-11743

KL-11743 is a potent glucose-competitive inhibitor of the class I glucose transporters with IC50s of 115, 137 and 90 nM for GLUT1, GLUT2, and GLUT3.

KL-11743 Chemical Structure

KL-11743 Chemical Structure

CAS No. 1369452-53-8

Purity & Quality Control

Batch: E080501 DMSO]100 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 98.98%
98.98

KL-11743 Related Products

Biological Activity

Description KL-11743 is a potent glucose-competitive inhibitor of the class I glucose transporters with IC50s of 115, 137 and 90 nM for GLUT1, GLUT2, and GLUT3.
Targets
GLUT3 [1]
(in the TiterGlo assay)		 GLUT1 [1]
(in the TiterGlo assay)		 GLUT2 [1]
(in the TiterGlo assay)
90 nM 115 nM 137 nM

Chemical Information & Solubility

Molecular Weight 522.60 Formula

C30H30N6O3
CAS No. 1369452-53-8 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (191.35 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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