Home Epigenetics Epigenetic Reader Domain inhibitor - Autophagy activator FL-411 For research use only.

FL-411

Synonyms: BRD4-IN-1

FL-411 (BRD4-IN-1) is a potent and selective inhibitor of Bromodomain-containing protein 4 (BRD4) with IC50 of 0.43 μM for BRD4(1). FL-411 induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction.

FL-411 Chemical Structure

FL-411 Chemical Structure

CAS No. 2118944-88-8

Purity & Quality Control

Batch: S102701 DMSO]10 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 98.13%
98.13

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Signaling Pathway

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Epigenetic Reader Domain Signaling Pathway

Biological Activity

Description FL-411 (BRD4-IN-1) is a potent and selective inhibitor of Bromodomain-containing protein 4 (BRD4) with IC50 of 0.43 μM for BRD4(1). FL-411 induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction.
Targets
BRD4(1) [1]
(Cell-free assay)
0.43 μM

Chemical Information & Solubility

Molecular Weight 341.43 Formula

C18H19N3O2S
CAS No. 2118944-88-8 SDF --
Smiles CC1=CC(=CC(=C1O)C)C2=NC3=C(C4=C(S3)CN(CC4)C)C(=O)N2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 10 mg/mL ( (29.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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