Home Neuronal Signaling Dopamine Receptor antagonist Droperidol For research use only.

Droperidol

Synonyms: NSC 169874,Dehydrobenzperidol

Droperidol (NSC 169874,Dehydrobenzperidol) is a potent antagonist of dopamine subtype 2 receptors in the limbic system.

Droperidol Chemical Structure

Droperidol Chemical Structure

CAS No. 548-73-2

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Droperidol Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Droperidol (NSC 169874,Dehydrobenzperidol) is a potent antagonist of dopamine subtype 2 receptors in the limbic system.
In vitro
In vitro

Droperidol produces mild α-adrenergic blockade and peripheral vascular dilation. Droperidol has been shown to block potassium efflux in the myocardium in isolated animal ventricular myocytes, resulting in a dose-dependent delay in repolarization. Droperidol has also been shown to induce early depolarizations in isolated animal Purkinje fibers. [1]
In Vivo
In vivo

Droperidol (0.01 mM-0.3 mM) increases in a dose-dependent fashion action potential duration (APD) without altering the other parameters in rabbit Purkinje fibers stimulated at 60 pulses/min. Droperidol (1 mM-3 mM) leads to the reversal of the prolonging effect in rabbit Purkinje fibers. Droperidol (10 mM-30 mM) produces shortening in APD at 50% repolarization concomitantly with a significant decrease in Vmax, action potential amplitude and resting membrane potential in rabbit Purkinje fibers. Droperidol exerts a dual effect on repolarization, prolongation with low concentrations with development of EADs and subsequent triggered activity in rabbit Purkinje fibers. [2] Droperidol (3 mg/kg, single dose) decreases dose dependently not only locomotion and rearing frequencies in the open-field but also the apomorphine effects of rats. Droperidol (3 mg/kg, long term administration) induces significant tolerance to all parameters of activity recorded in the open-field in rats. Droperidol withdrawn produces an augmented responsiveness to apomorphine-induced stereotyped behavior. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05759481 Recruiting
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Milton S. Hershey Medical Center
 February 1 2024 Phase 2
NCT05244460 Recruiting
Cannabis Hyperemesis Syndrome
Mercy Health Ohio|Lake Erie College of Osteopathic Medicine
 December 2 2021 Phase 3

Chemical Information & Solubility

Molecular Weight 379.43 Formula

C22H22FN3O2
CAS No. 548-73-2 SDF Download Droperidol SDF
Smiles C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 76 mg/mL ( (200.3 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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