Home Metabolism DHFR inhibitor Diaveridine For research use only.

Diaveridine

Synonyms: AI3-23935, CCRIS-3784

Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.

Diaveridine Chemical Structure

Diaveridine Chemical Structure

CAS No. 5355-16-8

Purity & Quality Control

Batch: S520001 DMSO]25 mg/mL]false]]]false]]]false Purity: 99.82%
99.82

Diaveridine Related Products

Signaling Pathway

DHFR Signaling Pathways

DHFR Signaling Pathway

Biological Activity

Description Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.
Targets
DHFR [1]
In vitro
In vitro Diaveridine (DVD) is a pyrimethamine analogue, a folic acid antagonist. It is also used as an antibacterial agent, especially for the respiratory and gastrointestinal tract infections in humans and animals. Diaveridine is genotoxic in mammalian cells in vitro and in vivo[1].
In Vivo
In vivo Acute tests indicate that the diaveridine has a high LD50 value and suggests a wide margin of safety for therapeutic doses[1].
Animal Research Animal Models Female and male Sprague Dawley rats and ICR mice
Dosages 780, 1131, 1640, 2378, 3448 and 5000 mg/kg for rats and 12, 452, 656, 951, 1379 and 2000 mg/kg for mice
Administration oral

Chemical Information & Solubility

Molecular Weight 260.29 Formula

C13H16N4O2
CAS No. 5355-16-8 SDF --
Smiles COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 25 mg/mL ( (96.04 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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