Home NF-κB HDAC inhibitor CXD101 For research use only.

CXD101

Synonyms: HDAC-IN-4

CXD101 (HDAC-IN-4) is a potent, selective and orally active class I histone deacetylase (HDAC) inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively.

CXD101 Chemical Structure

CXD101 Chemical Structure

CAS No. 934828-12-3

Purity & Quality Control

Batch: E081201 DMSO]81 mg/mL]false]Ethanol]10 mg/mL]false]Water]Insoluble]false Purity: 99.74%
99.74

CXD101 Related Products

Signaling Pathway

HDAC Signaling Pathways

HDAC Signaling Pathway

Biological Activity

Description CXD101 (HDAC-IN-4) is a potent, selective and orally active class I histone deacetylase (HDAC) inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively.
Targets
HDAC1 [1] HDAC3 [1] HDAC2 [1]
63 nM 550 nM 570 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03873025 Withdrawn
Diffuse Large B Cell Lymphoma
University College London|Celleron Therapeutics Ltd.|Merck Sharp & Dohme LLC
 October 2019 Phase 1|Phase 2
NCT01977638 Completed
Advanced Cancer
Oxford University Hospitals NHS Trust|University of Oxford|National Institute for Health Research United Kingdom|Cancer Research UK
 February 14 2014 Phase 1

Chemical Information & Solubility

Molecular Weight 403.52 Formula

C24H29N5O
CAS No. 934828-12-3 SDF --
Smiles C[N]1C=C(CN2CCC(CC2)C3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N)C(=N1)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 81 mg/mL ( (200.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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