Home Cell Cycle CDK inhibitor - DYRK inhibitor Cirtuvivint For research use only.

Cirtuvivint

Synonyms: SM08502

Cirtuvivint (SM08502) is a potent and orally active inhibitor of CDC-like kinase (CLK) and a DYRK (dual-specificity tyrosine kinase) that targets mRNA splicing and is optimized for Wnt pathway inhibition. Cirtuvivint inhibits serine and arginine-rich splicing factor (SRSF) phosphorylation and disrupts spliceosome activity. Cirtuvivint can be used for solid tumor research.

Cirtuvivint Chemical Structure

Cirtuvivint Chemical Structure

CAS No. 2143917-62-6

Purity & Quality Control

Cirtuvivint Related Products

Signaling Pathway

CDK Signaling Pathways

CDK Signaling Pathway

Biological Activity

Description Cirtuvivint (SM08502) is a potent and orally active inhibitor of CDC-like kinase (CLK) and a DYRK (dual-specificity tyrosine kinase) that targets mRNA splicing and is optimized for Wnt pathway inhibition. Cirtuvivint inhibits serine and arginine-rich splicing factor (SRSF) phosphorylation and disrupts spliceosome activity. Cirtuvivint can be used for solid tumor research.
Targets
CLK [1] DYRK [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03355066 Active not recruiting
Solid Tumor Adult
Biosplice Therapeutics Inc.
 November 6 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 427.50 Formula

C24H25N7O
CAS No. 2143917-62-6 SDF Download Cirtuvivint SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 22 mg/mL ( (51.46 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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