Home Neuronal Signaling Dopamine Receptor agonist Cariprazine hydrochloride For research use only.

Cariprazine hydrochloride

Synonyms: RGH188 hydrochloride

Cariprazine hydrochloride(RGH188 hydrochloride) is a novel antipsychotic agent and is a highly selective partial agonist of dopamineD2 and D3 and 5HT1A receptors, with preferential binding to the D3 receptor. It exhibits high selectivity and affinity to dopamine D3 (Ki = 0.085 nM) and D2 (Ki = 0.49 nM) receptors and has moderate affinity for the 5-HT1A receptor (Ki = 2.6 nM).

Cariprazine hydrochloride Chemical Structure

Cariprazine hydrochloride Chemical Structure

CAS No. 1083076-69-0

Purity & Quality Control

Batch: S723601 DMSO]12 mg/mL]false]Ethanol]12 mg/mL]false]Water]Insoluble]false Purity: 99.65%
99.65

Cariprazine hydrochloride Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Cariprazine hydrochloride(RGH188 hydrochloride) is a novel antipsychotic agent and is a highly selective partial agonist of dopamineD2 and D3 and 5HT1A receptors, with preferential binding to the D3 receptor. It exhibits high selectivity and affinity to dopamine D3 (Ki = 0.085 nM) and D2 (Ki = 0.49 nM) receptors and has moderate affinity for the 5-HT1A receptor (Ki = 2.6 nM).
Targets
dopamine D3 receptor [2] Dopamine D2 receptor [2] 5HT1A receptor [2]
0.085 nM(Ki) 0.49 nM(Ki) 2.6 nM(Ki)

Chemical Information & Solubility

Molecular Weight 463.87 Formula

C21H32Cl2N4O.HCl
CAS No. 1083076-69-0 SDF Download Cariprazine hydrochloride SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 12 mg/mL ( (25.86 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 12 mg/mL

Water : Insoluble


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In vivo
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