Home GPCR & G Protein Guanylate Cyclase agonist BAY 41-2272 For research use only.

BAY 41-2272

BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.

BAY 41-2272 Chemical Structure

BAY 41-2272 Chemical Structure

CAS No. 256376-24-6

Purity & Quality Control

Batch: S812801 DMSO]35 mg/mL]false]Ethanol]4 mg/mL]false]Water]Insoluble]false Purity: 99.96%
99.96

BAY 41-2272 Related Products

Biological Activity

Description BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
Targets
Guanylate cyclase [1]
In vitro
In vitro In vitro, BAY 41-2272 results in concentration dependent relaxation of human and rabbit cavernosum with EC50 of 489.1 nM and 406.3 nM, respectively. [3]
In Vivo
In vivo In female spontaneously hypertensive rats, BAY 41-2272 (10 mg/kg, p.o.) shows antiplatelet effect, strongly decreases blood pressure and increases survival. [2] In C. albicans-infected mice, BAY 41-2272 (10 mg/kg, i.p.) markedly increases macrophage-dependent cell influx to the peritoneum in addition to macrophage functions, and reduces the death rate. [4] In db/db-/- type II diabetic and obese mice, BAY 41-2272 improves impaired corpus cavernosum (CC) relaxation. [5]
Animal Research Animal Models Female spontaneously hypertensive rats
Dosages 1 mg/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 360.39 Formula

C20H17FN6
CAS No. 256376-24-6 SDF Download BAY 41-2272 SDF
Smiles C1CC1C2=CN=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 35 mg/mL ( (97.11 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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