Home GPCR & G Protein Glucagon Receptor agonist Apraglutide (FE 203799) For research use only.

Apraglutide (FE 203799)

Apraglutide (FE 203799) is a potent and highly selective GLP-2 agonist with EC50s of 0.03 nM and 0.07 nM for hGLP-2 Receptor and rGLP-2 Receptor, respectively.

Apraglutide (FE 203799) Chemical Structure

Apraglutide (FE 203799) Chemical Structure

CAS No. 1295353-98-8

Purity & Quality Control

Batch: E002101 DMSO]100 mg/mL]false]Water]Insoluble]false]]]false Purity: 99.74%
99.74

Apraglutide (FE 203799) Related Products

Biological Activity

Description

Apraglutide (FE 203799) is a potent and highly selective GLP-2 agonist with EC50s of 0.03 nM and 0.07 nM for hGLP-2 Receptor and rGLP-2 Receptor, respectively.
Targets
hGLP-2 Receptor [1] rGLP-2 Receptor [1]
0.03 nM(EC50) 0.07 nM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06002555 Completed
Healthy Subjects
VectivBio AG
 May 23 2023 Phase 1
NCT05995704 Completed
Healthy Subjects
VectivBio AG
 March 2 2023 Phase 1
NCT05706623 Completed
Hepatic Impairment
VectivBio AG
 January 30 2023 Phase 1
NCT05415410 Active not recruiting
GVHD
VectivBio AG
 May 25 2022 Phase 2
NCT04964986 Completed
Short Bowel Syndrome
VectivBio AG
 June 14 2021 Phase 2
NCT04627025 Completed
Short Bowel Syndrome
VectivBio AG
 January 26 2021 Phase 3

Chemical Information & Solubility

Molecular Weight 3765.25 Formula

C172H263N43O52
CAS No. 1295353-98-8 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (26.55 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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