Home Microbiology Reverse Transcriptase inhibitor Abacavir sulfate For research use only.

Abacavir sulfate

Synonyms: 1592U89

Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

Abacavir sulfate Chemical Structure

Abacavir sulfate Chemical Structure

CAS No. 188062-50-2

Purity & Quality Control

Abacavir sulfate Related Products

Signaling Pathway

Reverse Transcriptase Signaling Pathways

Reverse Transcriptase Signaling Pathway

Biological Activity

Description Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
Targets
HIV-1 reverse-transcriptase [1]
In vitro
In vitro Abacavir is an analog of guanosine (a purine). Its target is the viral reverse transcriptase enzyme.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04133012 Completed
HIV-1 Infection
ANRS Emerging Infectious Diseases|ViiV Healthcare
 February 10 2020 Not Applicable
NCT02708342 Completed
HIV
IRCCS San Raffaele|Merck Sharp & Dohme LLC
 April 2016 --

Chemical Information & Solubility

Molecular Weight 335.35 Formula

C14H18N6O.1/2 H2SO4
CAS No. 188062-50-2 SDF Download Abacavir sulfate SDF
Smiles C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 67 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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