Home Neuronal Signaling AChR antagonist Ipratropium Bromide For research use only.

Ipratropium Bromide

Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).

Ipratropium Bromide Chemical Structure

Ipratropium Bromide Chemical Structure

CAS No. 22254-24-6

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Ipratropium Bromide Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).
Targets
mAChR [1]
In vitro
In vitro Ipratropium bromide combined with Formoterol partially protects the lungs against the chronic inflammation and airspace enlargement by reducing neutrophilic infiltration possibly via the inhibition of MMP-9 activity. [1] Ipratropium bromide (1 nM) significantly increases [Ca(2+)](i), decreases forward scatter and increases annexin-V-binding. Ipratropium bromide treatment is followed by slight but significant increase of hemolysis. Ipratropium bromide triggers suicidal erythrocyte death or eryptosis, an effect mainly due to stimulation of Ca(2+)-entry. [2]
In Vivo
In vivo Ipratropium dry powder inhalation (DPI) at a dose of 2400 mg/horse is an effective bronchodilator in these horses at rest but it has little effect on the airway calibre during the recovery period. [3] Ipratropium significantly attenuates the lung lesions associated with parenchyma inflammatory cell influx and congestion observed in the cadmium treated rats. Ipratropium bromide partially protects the lungs against the inflammation by reducing neutrophilic infiltration. [4] Ipratropium is an antagonist for pre-junctional muscarinic inhibitory receptors on pulmonary parasympathetic nerves and also confirms its potent antagonist actions on post-junctional muscarinic receptors in the airway smooth muscle in the guinea-pig. [5] Ipratropium decreases the maximal change in pleural pressure during tidal breathing (delta Pplmax) and pulmonary resistance (RL) and increases dynamic compliance (Cdyn) in horse. [6]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06110481 Recruiting
Bronchopulmonary Dysplasia|Chronic Lung Disease of Prematurity|Chronic Lung Disease of Newborn|Preterm Birth Complication|Bronchial Hyperreactivity|Bronchial Obstruction|Reversible Dilatation
Charles University Czech Republic
 April 1 2021 --
NCT04617015 Completed
Asthma|Depression|Childhood Asthma
State University of New York at Buffalo|National Center for Advancing Translational Sciences (NCATS)
 September 9 2016 Early Phase 1
NCT01691079 Completed
Bronchospasm Exercise-Induced
University of California San Francisco
 December 2012 Phase 4

Chemical Information & Solubility

Molecular Weight 412.37 Formula

C20H30BrNO3
CAS No. 22254-24-6 SDF Download Ipratropium Bromide SDF
Smiles CC(C)[N+]1(C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C.[Br-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 83 mg/mL ( (201.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 83 mg/mL

Ethanol : 83 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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