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Clonidine HCl

Synonyms: Kapvay

Clonidine HCl(Kapvay) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.

Clonidine HCl Chemical Structure

Clonidine HCl Chemical Structure

CAS No. 4205-91-8

Purity & Quality Control

Batch: S245801 DMSO]53 mg/mL]false]Water]53 mg/mL]false]Ethanol]53 mg/mL]false Purity: 99.97%
99.97

Clonidine HCl Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Clonidine HCl(Kapvay) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.
Targets
α2-adrenergic receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05943613 Not yet recruiting
Postoperative Pain
Assiut University
 December 1 2023 Phase 1
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Emergence Delirium
Rigshospitalet Denmark
 October 25 2021 Phase 2|Phase 3
NCT05029401 Unknown status
Opiate Withdrawal Syndrome
DemeRx IB Inc.|MAC Clinical Research|ERT: Clinical Trial Technology Solutions|Hammersmith Medicines Research
 April 1 2021 Phase 1|Phase 2
NCT03537612 Terminated
Scoliosis
Dr. Jean A. Ouellet MD FRCSC|Shriners Hospitals for Children
 June 22 2018 Phase 3

Chemical Information & Solubility

Molecular Weight 266.5 Formula

C9H9Cl2N3.HCl
CAS No. 4205-91-8 SDF Download Clonidine HCl SDF
Smiles C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 53 mg/mL ( (198.87 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 53 mg/mL

Ethanol : 53 mg/mL


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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