Home Neuronal Signaling Histamine Receptor inhibitor Cetirizine DiHCl For research use only.

Cetirizine DiHCl

Synonyms: Zyrtec, Reactine,UCB P071

Cetirizine DiHCl (Zyrtec, Reactine,UCB P071) is an antihistamine.

Cetirizine DiHCl Chemical Structure

Cetirizine DiHCl Chemical Structure

CAS No. 83881-52-1

Purity & Quality Control

Cetirizine DiHCl Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Cetirizine DiHCl (Zyrtec, Reactine,UCB P071) is an antihistamine.
Targets
Histamine receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00779116 Completed
Allergies
Organon and Co
 September 2005 Phase 4
NCT00780403 Completed
Allergies
Organon and Co
 August 2005 Phase 4

Chemical Information & Solubility

Molecular Weight 461.81 Formula

C21H25ClN2O3.2HCl
CAS No. 83881-52-1 SDF Download Cetirizine DiHCl SDF
Smiles C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 92 mg/mL ( (199.21 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 92 mg/mL

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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