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Cephalexin

Synonyms: Cefalexin

Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.

Cephalexin Chemical Structure

Cephalexin Chemical Structure

CAS No. 15686-71-2

Purity & Quality Control

Cephalexin Related Products

Biological Activity

Description Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.
In vitro
In vitro Cephalexin uptake by human MATE1-expressing human embryonic kidney 293 cells exhibits saturable kinetics with K(m) = 5.9 mM and a bell-shaped pH profile with a maximum at pH 7.0. [1] Cephalexin results in overestimation of glucose concentration, but only in the samples that contain the highest antimicrobial concentration (2,400microg/mL) and only for the tablet. [2] Cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells. [3]
In Vivo
In vivo Cephalexin causes a slight prolongation of 1-stage prothrombin time (PT) and activated partial thromboplastin time (PTT) and slight decrease in fibrinogen concentration in healthy dogs. Cephalexin causes a significant increase in 1-stage PT and activated PTT, amoxicillin causes a significant increase in activated PTT, and enrofloxacin causes a significant decrease in fibrinogen concentration. [4] Cephalexin results in high numbers of E. coli producing plasmid-mediated CMY-2 β-lactamase at the end of the treatment period in dogs. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04916951 Enrolling by invitation
Neonatal Infection
University of Colorado Denver
 July 14 2021 Phase 1
NCT03802552 Completed
Osteomyelitis|Septic Arthritis|Pyomyositis
University of Colorado Denver
 May 1 2019 Phase 1
NCT02490670 Completed
Healthy
Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.
 July 2015 Phase 1
NCT02123459 Completed
Healthy Volunteers
Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.
 May 2014 Phase 1
NCT02123472 Completed
Healthy Volunteers
Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.
 May 2014 Phase 1

Chemical Information & Solubility

Molecular Weight 347.39 Formula

C16H17N3O4S
CAS No. 15686-71-2 SDF Download Cephalexin SDF
Smiles CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=CC=C3)N)SC1)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 10 mg/mL

DMSO : 5 mg/mL ( (14.39 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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