Home Apoptosis p38 MAPK inhibitor 3,4',5-Trimethoxy-trans-stilbene For research use only.

3,4',5-Trimethoxy-trans-stilbene

Synonyms: MR-3

3,4',5-Trimethoxy-trans-stilbene (MR-3) is a methylated derivative of resveratrol and shows more potent inhibitory effects on the growth of human cancer cells (HT-29, PC-3, COLO 205) with IC50 values of 81.31, 42.71 and 6.25 μM, respectively.

3,4',5-Trimethoxy-trans-stilbene Chemical Structure

3,4',5-Trimethoxy-trans-stilbene Chemical Structure

CAS No. 22255-22-7

Purity & Quality Control

Batch: S388801 DMSO]54 mg/mL]false]]]false]]]false Purity: 99.83%
99.83

3,4',5-Trimethoxy-trans-stilbene Related Products

Signaling Pathway

p38 MAPK Signaling Pathways

p38 MAPK Signaling Pathway

Biological Activity

Description 3,4',5-Trimethoxy-trans-stilbene (MR-3) is a methylated derivative of resveratrol and shows more potent inhibitory effects on the growth of human cancer cells (HT-29, PC-3, COLO 205) with IC50 values of 81.31, 42.71 and 6.25 μM, respectively.
In vitro
In vitro Treatment with MR-3 at different concentrations ranging from 0 to 10 μM exhibits no cytotoxic effects on the A549 cells. MR-3 inhibits adhesion, migration, and invasion of A549 cells. The anti-invasive effects of MR-3 on A549 cells are likely mediated through the inhibition of phosphorylation of JNK and p38, as well as a reduction in the protein levels of nuclear factorkappa B (NF-kB) and activator protein-1 (AP-1) in the nucleus, ultimately leading to downregulation of MMP-2 expression[1].
Cell Research Cell lines A549 cells
Concentrations 1, 5, 10, 25, 50, or 100 μM
Incubation Time 24 h
Method The A549 cells are treated with MR-3 at various concentrations (1, 5, 10, 25, 50, or 100 μM) for 24 h. Cell viability is assassed by MTT assay.

Chemical Information & Solubility

Molecular Weight 270.32 Formula

C17H18O3
CAS No. 22255-22-7 SDF Download 3,4',5-Trimethoxy-trans-stilbene SDF
Smiles COC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC)OC
Storage (From the date of receipt)

In vitro
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DMSO : 54 mg/mL ( (199.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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