Safety Data Sheet

1. Identification of substance

Product Name	Sabatolimab (anti-TIM-3)
Cat. Number	A2037
Manufacturer/Supplier	Selleck Chemicals 14408 W Sylvanfield Drive, Houston, TX 77014 USA Toll Free：(877) 796-6397 (US and Canada only) Tel：+1-832-582-8158 Fax：+1-832-582-8590

2. Composition/data on components

Chemical Name
Synonyms	MBG453, NVP-MBG453
Hazardous Ingredient	Sabatolimab (anti-TIM-3)
CAS Registry Number	2252262-24-9
Molecular Weight	145 KD

3. Hazard identification

Hazard Description	Toxic. Contains a pharmaceutically active ingredient. Handling should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

4. First aid measures

After Inhalation	if inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact	flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact	check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing	if swallowed, wash out mouth with copious amounts of water; call a physician

5. Fire fighting measures

Suitable extinguishing agents	water spray, carbon dioxide, dry chemical powder or foam
Protective equipment	wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard	emits toxic fumes such as carbon monoxide, etc.

6. Accidental release measures

Suitable extinguishing agents	water spray, carbon dioxide, dry chemical powder or foam
Protective equipment	wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard	emits toxic fumes such as carbon monoxide, etc.

7. Handling

Information for safe handling	avoid inhalation and contact with skin, eyes and clothing; material may be an irritant

8. Exposure controls and personal protection

Personal protective equipment as follows

Breathing equipment	NIOSH/MSHA-approved respirator
Protection of hands	chemical-resistant rubber gloves
Eye protection	chemical safety goggles

9. Stability and reactivity

Stability	stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided:	protect from light and heat
Dangerous products of decomposition	thermal ecomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides

10. Toxicological information

RTECS#

Acute toxicity	none known
Primary irritant effect	not known
On the skin	none known
On the eye	not known; may be an irritant

11. Ecological information

General notes	no data available

12. Disposal consideration

Dispose of in accordance with prevailing country, federal, state and local regulations

13. Transport information

DOT

Proper shipping name	none
Non-Hazardous for transport	this substance is considered to be non-hazardous for transport

IATA class

IATA class	none
Non-Hazardous for transport	this substance is considered to be non-hazardous for transport

14.Regulations

Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:

• S24/25: avoid contact with skin and eyes
• S26: in case of contact with eyes, rinse immediately with plenty of water and seek medical advice
• S28: after contact with skin, wash immediately with plenty of water
• S36/37/39: wear protective clothing, gloves and eye/face protection
• R28: very toxic if swallowed
• R38: irritating to skin
• R41: risk of serious damages to eyes
• R48: toxic; danger of serious damage to health by prolonged exposure

R62: possible risk of impaired fertility

R63: possible risk of harm to unborn child

15.Other information

The above information is believed to be correct based on our present knowledge but does not purport to be complete. The product is for research use only and for trained personnel. The burden of safe use of this material rests entirely with the user. SELLECK CHEMICALS disclaims all liability for any damage resulting from use of this material.