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Safety Data Sheet
Revision Date: May 1, 2014
1. Identification of substance
| Product Name | Nirogacestat (PF-03084014) |
|---|---|
| Cat. Number | S8018 |
| Manufacturer/Supplier | Selleck Chemicals 14408 W Sylvanfield Drive, Houston, TX 77014 USA Toll Free：(877) 796-6397 (US and Canada only) Tel：+1-832-582-8158 Fax：+1-832-582-8590 |
2. Composition/data on components
| Chemical Name | 2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]-(2S)-pentanamide |
|---|---|
| Synonyms | N/A |
| Hazardous Ingredient | Nirogacestat (PF-03084014) |
| CAS Registry Number | 1290543-63-3 |
| Molecular Weight | 489.64 |
| Molecular Formula | C27H41F2N5O |
3. Hazard identification
| Hazard Description | Toxic. Contains a pharmaceutically active ingredient. Handling should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes. |
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4. First aid measures
| After Inhalation | if inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration |
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| After skin contact | flush with copious amounts of water; remove contaminated clothing and shoes; call a physician |
| After eye contact | check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician |
| After swallowing | if swallowed, wash out mouth with copious amounts of water; call a physician |
5. Fire fighting measures
| Suitable extinguishing agents | water spray, carbon dioxide, dry chemical powder or foam |
|---|---|
| Protective equipment | wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. |
| Unusual fire hazard | emits toxic fumes such as carbon monoxide, etc. |
6. Accidental release measures
| Suitable extinguishing agents | water spray, carbon dioxide, dry chemical powder or foam |
|---|---|
| Protective equipment | wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. |
| Unusual fire hazard | emits toxic fumes such as carbon monoxide, etc. |
7. Handling
| Information for safe handling | avoid inhalation and contact with skin, eyes and clothing; material may be an irritant |
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8. Exposure controls and personal protection
| Breathing equipment | NIOSH/MSHA-approved respirator |
|---|---|
| Protection of hands | chemical-resistant rubber gloves |
| Eye protection | chemical safety goggles |
9. Stability and reactivity
| Stability | stable if stored as directed; avoid strong oxidizing agents |
|---|---|
| Thermal decomposition / conditions to be avoided: | protect from light and heat |
| Dangerous products of decomposition | thermal ecomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides |
10. Toxicological information
| Acute toxicity | none known |
|---|---|
| Primary irritant effect | not known |
| On the skin | none known |
| On the eye | not known; may be an irritant |
11. Ecological information
| General notes | no data available |
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12. Disposal consideration
Dispose of in accordance with prevailing country, federal, state and local regulations
13. Transport information
| Proper shipping name | none |
|---|---|
| Non-Hazardous for transport | this substance is considered to be non-hazardous for transport |
| IATA class | none |
|---|---|
| Non-Hazardous for transport | this substance is considered to be non-hazardous for transport |
14.Regulations
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
- S24/25: avoid contact with skin and eyes
- S26: in case of contact with eyes, rinse immediately with plenty of water and seek medical advice
- S28: after contact with skin, wash immediately with plenty of water
- S36/37/39: wear protective clothing, gloves and eye/face protection
- R28: very toxic if swallowed
- R38: irritating to skin
- R41: risk of serious damages to eyes
- R48: toxic; danger of serious damage to health by prolonged exposure
R62: possible risk of impaired fertility
R63: possible risk of harm to unborn child
15.Other information
The above information is believed to be correct based on our present knowledge but does not purport to be complete. The product is for research use only and for trained personnel. The burden of safe use of this material rests entirely with the user. SELLECK CHEMICALS disclaims all liability for any damage resulting from use of this material.