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Technical Data
| Formula | C21H19BrClN5O4S2 |
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| Molecular Weight | 584.89 | CAS No. | 587841-73-4 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (170.97 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. | ||
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| In vitro | ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity. [1] |
Protocol (from reference)
Customer Product Validation
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, , Cell Physiol Biochem, 2015, 36(4):1613-27.
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Data from [Data independently produced by , , J Bone Miner Res, 2018, 33(5):945-958]
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Data from [Data independently produced by , , J Virol, 2017, 91(5)]
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Data from [Data independently produced by , , J Cell Physiol, 2018, doi:10.1002/jcp.27510]
Selleck's ZCL278 has been cited by 14 publications
| Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer [ Cancer Commun (Lond), 2023, 43(8):909-937] | PubMed: 37434399 |
| ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42 [ J Exp Clin Cancer Res, 2022, 41(1):230] | PubMed: 35869555 |
| GEFT Inhibits Autophagy and Apoptosis in Rhabdomyosarcoma via Activation of the Rac1/Cdc42-mTOR Signaling Pathway [ Front Oncol, 2021, 11:656608] | PubMed: 34221974 |
| NecroX-5 Can Suppress Melanoma Metastasis by Reducing the Expression of Rho-Family GTPases [ J Clin Med, 2021, 10(13)2790] | PubMed: 34201921 |
| Epigenetically upregulated GEFT-derived invasion and metastasis of rhabdomyosarcoma via epithelial mesenchymal transition promoted by the Rac1/Cdc42-PAK signalling pathway. [ EBioMedicine, 2019, 50:122-134] | PubMed: 31761617 |
| Cdc42 Is Essential for Both Articular Cartilage Degeneration and Subchondral Bone Deterioration in Experimental Osteoarthritis [Hu X J Bone Miner Res, 2018, 33(5):945-958] | PubMed: 29314205 |
| Intersectin-Cdc42 interaction is required for orderly meiosis in porcine oocytes [Li X J Cell Physiol, 2018, 10.1002/jcp.27510] | PubMed: 30478952 |
| CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes [ BMC Biol, 2018, 16(1):73] | PubMed: 29976179 |
| Interaction of the Small GTPase Cdc42 with Arginine Kinase Restricts White Spot Syndrome Virus in Shrimp [Xu JD J Virol, 2017, 91(5)] | PubMed: 28031362 |
| Exosomal miR-141-3p regulates osteoblast activity to promote the osteoblastic metastasis of prostate cancer [ Oncotarget, 2017, 8(55):94834-94849] | PubMed: 29212270 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.