YK-4-279

Catalog No.S7679 Batch:S767901

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Technical Data

Formula

C17H13Cl2NO4

Molecular Weight 366.20 CAS No. 1037184-44-3
Solubility (25°C)* In vitro DMSO 73 mg/mL (199.34 mM)
Ethanol 51 mg/mL (139.26 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).
Targets
RHA [1]
In vitro YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. YK-4-279 also specifically inhibits ESFT cell growth and induces apoptosis. [1] YK-4-279 also inhibits ERG and ETV1 biological activity in fusion-positive prostate cancer cells, and further decreases cell motility and invasion. [2]
In vivo In vivo, YK-4-279 (1.5 mg/dose i.p.) inhibits the growth of ESFT xenograft tumors. [1] In mouse model, YK-4-279 selectively prevents prostate cancer growth and metastasis in fusion-positive LNCaP-luc-M6 tumors. [3]

Protocol (from reference)

Animal Study:[1]
  • Animal Models

    Nude mice bearing prostate cancer PC3, TC71 or CHP-100 xenografts

  • Dosages

    1.5 mg/dose

  • Administration

    i.p.

Customer Product Validation

Data from [Data independently produced by , , Oncotarget, 2017, 8(55):94780-94792]

Selleck's YK-4-279 has been cited by 14 publications

FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity [ Nat Commun, 2024, 15(1):4590] PubMed: 38816360
High-Content and High-Throughput Clonogenic Survival Assay Using Fluorescence Barcoding [ Cancers -Basel), 2023, 15(19)4772] PubMed: 37835466
TK216 targets microtubules in Ewing sarcoma cells [ Cell Chem Biol, 2022, 29(8):1325-1332.e4] PubMed: 35803262
The ETS Inhibitor YK-4-279 Suppresses Thyroid Cancer Progression Independent of TERT Promoter Mutations [ Front Oncol, 2021, 11:649323] PubMed: 34221969
Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup [ Clin Cancer Res, 2020, 26(14):3819-3830] PubMed: 32317288
Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup [ Clin Cancer Res, 2020, 21;clincanres35732019] PubMed: 32317288
p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction [ Cancers (Basel), 2020, 12(11)E3205] PubMed: 33143299
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. [ Cell, 2019, 36(2):179-193] PubMed: 28162770
A Pharmacogenomic Landscape in Human Liver Cancers. [ Cancer Cell, 2019, 36(2):179-193] PubMed: 31378681
Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro. [ Antiviral Res, 2019, 170:104570] PubMed: 31362004

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.